Relapse in T cell acute lymphoblastic leukemia (T-ALL) constitutes a challenge. A subclonal population of bone marrow progenitor-like cells present in all T-ALL genetic or immunophenotypic subtypes is now shown to confer chemoresistance and poor prognosis, and to be targetable with anti-apoptotic agents.
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Elitzur, S., Izraeli, S. Bone marrow progenitor-like cells against leukemia cure. Nat Cancer 6, 18–19 (2025). https://doi.org/10.1038/s43018-024-00864-4
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DOI: https://doi.org/10.1038/s43018-024-00864-4
