The tumor microenvironment has a crucial role in tumor progression and metastasis formation. A single-cell analysis now compares the microenvironments of primary tumor and peritoneal metastases in colorectal cancer and shows that neutrophils and fibroblasts contribute to the unique biology of peritoneal metastatic disease.
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Q.R. and L.V. are both employees of Genentech and shareholders of Roche.
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Ren, Q., Vermeulen, L. Shaping the microenvironment in peritoneal metastases. Nat Cancer 6, 412–414 (2025). https://doi.org/10.1038/s43018-024-00878-y
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DOI: https://doi.org/10.1038/s43018-024-00878-y
