Extended Data Fig. 9: ETV7 orchestrates memory and exhaustion gene expression in CD8+ T cells of tumor patients and HCV infection patients. | Nature Cancer

Extended Data Fig. 9: ETV7 orchestrates memory and exhaustion gene expression in CD8+ T cells of tumor patients and HCV infection patients.

From: ETV7 limits the antiviral and antitumor efficacy of CD8+ T cells by diverting their fate toward exhaustion

Extended Data Fig. 9

a, b, Genomic traces of aggregated scATAC-seq data from basal cell carcinoma and renal cell carcinoma patients showing chromatin accessibility around CXCR4, EOMES, CXCR5, HAVCR2 and CXCL13 in memory and exhausted T (Tex) cell clusters. The location of the predicted binding motifs of ETV7 is marked at the bottom (a). The shaded bars in graphs mark peaks with the binding motif of ETV7. The p-value and location of the predicted binding motifs of ETV7 (b). c, Heatmap of opened and closed peaks with ETV7 binding motif from naïve, memory to exhaustion of CD8+ T cells from HCV infected patients. Targeted memory genes and exhaustion genes as well as ETV7 were shown (CCR4, TCF7, CTLA4, and TOX).

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