Extended Data Fig. 8: IL24, cDC2 and effector CD4 + T cell genes in breast cancer. | Nature Cancer

Extended Data Fig. 8: IL24, cDC2 and effector CD4 + T cell genes in breast cancer.

From: Adoptively transferred tumor-specific IL-9-producing cytotoxic CD8+ T cells activate host CD4+ T cells to control tumors with antigen loss

Extended Data Fig. 8

a, Prognostic value of IL24 expression for overall survival of breast cancer patients comparing high versus low quartiles (n = 263 per group). b, Correlation of IL24 and cDC2 signature in breast cancer patients (n = 1050). c, d, Heatmap (n = 1050) of ordered, z-transformed expression values of cDC2-specific genes and expression of cDC2 signature genes for top and bottom quartiles (n = 263 per group) in breast cancer patients. e, Prognostic value of cDC2 signature or CD1C expression for overall survival of breast cancer patients comparing high versus low quartiles (n = 263 per group). f, g, Heatmap (n = 1050) of ordered, z-transformed expression values of effector CD4+ T cell-specific genes and expression of effector CD4+ T cell-specific signature genes for top and bottom quartiles (n = 263 per group) in breast cancer patients. h, Prognostic value of effector CD4+ T cell signature expression for overall survival in breast cancer patients comparing high versus low quartiles (n = 263 per group). (i) Correlation of effector CD4+ T cell signature with IL24 or with cDC2 signature in breast cancer patients (n = 1050). Data are presented as mean ± SEM. The log-rank (Mantel–Cox) test was performed to compare survival curves in a, e, h; Linear regression were used in b and i.

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