Extended Data Fig. 9: Schematic diagram of the study. | Nature Cancer

Extended Data Fig. 9: Schematic diagram of the study.

From: Adoptively transferred tumor-specific IL-9-producing cytotoxic CD8+ T cells activate host CD4+ T cells to control tumors with antigen loss

Extended Data Fig. 9

After adoptive T cell transfer, antigen-positive tumor cells lost their primary antigens. Adoptively transferred Tc9 cells not only killed antigen-expressing primary tumors but also secreted high levels of IL-24, which recruited dendritic cells (DCs), particularly cDC2, to the tumor microenvironment. cDC2 then migrated to tumor-draining lymph nodes (tdLNs) in a CCR7-dependent manner, where they activated host Th1-like effector CD4+ T cells. These activated CD4+ T cells subsequently infiltrated tumors and contributed to controlling ALV tumor growth.

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