Extended Data Fig. 2: DOT cells establish immunological synapses with both MSI and MSS CRC cells lines. | Nature Cancer

Extended Data Fig. 2: DOT cells establish immunological synapses with both MSI and MSS CRC cells lines.

From: Dual modulation of cytotoxic and checkpoint receptors tunes the efficacy of adoptive Delta One T cell therapy against colorectal cancer

Extended Data Fig. 2

(a) Representative images of image flow cytometry data of immunological synapses formed between DOT cells and different CRC cell lines. (b) Quantification of filamentous actin (F-actin) signal within the area of interaction between DOT cells and tumor cells (n= 88 HCT116, n= 64 DLD1, n=183 SW620, n= 89 COLO320 doublets), compared with the signal in DOT:DOT cell doublets (n= 183 doublets). Data represented as means ± SEM and were analyzed with Kruskal-Wallis with Dunn’s multiple comparisons test.

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