Extended Data Fig. 1: DOT-cell phenotype. | Nature Cancer

Extended Data Fig. 1: DOT-cell phenotype.

From: Dual modulation of cytotoxic and checkpoint receptors tunes the efficacy of adoptive Delta One T cell therapy against colorectal cancer

Extended Data Fig. 1

(a) Density plots represent an example of the purity of γδ T cells and Vδ1+ T cells after DOT cell expansion/differentiation from PBMCs from healthy volunteers (b) Representative percentages of NKG2D, DNAM-1 and NKp30, gated on Vδ1+ T cells. (c) Degranulation (CD107a), Granzyme B and Perforin production and cytokine expression after 3h PMA/Ionomycin stimulation in the presence of protein translocator inhibitors in a representative DOT donor.

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