Extended Data Fig. 4: Genetic dynamics and expression of EAC driver genes during treatment.
Number of altered (CNA, SNV or indel) genes from 108 EAC drivers in (a) the overall cohort, (b) NRPs (left) and REPs (right). Number of driver genes with CNAs (c) in the overall cohort, (d) in NRPs (left) and REPs (right). Number of driver genes with SNVs or indels (e) in the overall cohort, (f) in NRPs (left) and REPs (right). (g) Violin plots show expression of 16 high-frequency EAC driver genes during neoadjuvant treatment. P values in all panels are calculated by the two-sided Wilcoxon test. cpm: counts per million.
