Extended Data Fig. 5: Cancer type and patient specificity of cell type expression profiles.
a. Scheme illustrating the definition of cancer type and patient specificity in terms of pairwise correlations of pseudobulk profiles. b. Box plot showing the patient specificity (y axis) of each cell type (x axis) in each cancer type (points/colour). Brackets indicate significant differences and are labelled with p values (0.0091 and 0.017), which were computed by pairwise paired, two-sided t tests and adjusted to FDR < 0.05 (all p values are provided in the Source Data). Unmarked pairwise differences are not significant. Boxes indicate the median and 1st and 3rd quartiles, while the upper, respectively the lower whiskers extend to the maximal, resp. minimal values no further than 1.5 times the interquartile range from the 3rd, resp. 1st quartiles. Groups (cell types) consist of n = 15, 11, 11, 11, 10, 8, 16 data points (in order from left to right), corresponding to averages across pairwise correlations between biologically distinct samples.
