Extended Data Fig. 8: Abundance of cell types in B-ALL and MPAL. | Nature Cancer

Extended Data Fig. 8: Abundance of cell types in B-ALL and MPAL.

From: Multipotent lineage potential in B cell acute lymphoblastic leukemia is associated with distinct cellular origins and clinical features

Extended Data Fig. 8

Comparison of B cell Developmental State abundance between uniformly processed MPAL (n = 66) and B-ALL (n = 1,153) patient samples. Abundance of HSC/MPP/LMPP, early lymphoid, myeloid progenitor, pre-pDC, pro-B and pre-B in early/multipotent (early/multip.) and committed subgroups of BCR::ABL1 (n = 50 and n = 57, respectively), KMT2A-R (n = 69 and n = 10, respectively) and ZNF384-R (n = 53) with B-ALL and in ‘Other B-ALL’ (n = 793, non-BCR::ABL1, non-KMT2A-R and non-ZNF384-R), and in MPAL patients with same genetic drivers: BCR::ABL1 (n = 4), KMT2A-R (n = 13) and ZNF384-R (n = 13) or ‘Other’ (n = 36). For each comparison, P values from a two-tailed Wilcoxon rank-sum test are reported. Box plots indicate the range of the central 50% of the data, with the central line marking the median. Whiskers extend from each box to 1.5x the interquartile range.

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