Extended Data Fig. 9: Regional reprogramming in human prostate tumors. | Nature Cancer

Extended Data Fig. 9: Regional reprogramming in human prostate tumors.

From: Innate immunity and the NF-κB pathway control prostate stem cell plasticity, reprogramming and tumor initiation

Extended Data Fig. 9

(a) Cell populations on ERG-driven human prostate cancer cells, human prostate cancer atlas, treatment-naïve prostate adenocarcinoma and invasive cribriform carcinoma and intraductal carcinoma data. (b) UMAP dimensionality reduction plots for KRT13 and WFDC2 with color scaling representing the level of gene expression. (c-f) Heatmap of reprogramming marker genes defined on K5-PTEN 6 W scRNA-seq data on (c) ERG-driven human prostate cancer cells, (d) human prostate cancer atlas, (e) treatment-naïve prostate adenocarcinoma and (f) invasive cribriform carcinoma and intraductal carcinoma data. (g-i) Slingshot pseudotime trajectory analysis illustrating the lineage trajectory on (g) ERG-driven human prostate cancer cells, (h) human prostate cancer atlas and (i) invasive cribriform carcinoma and intraductal carcinoma data. (j) Summary of IHC staining results for PIGR and AQP3 in prostate tumor samples from 136 patients, categorized by GG groups of prostate cancer. Green boxes indicate co-staining of PIGR and AQP3.

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