Fig. 5: Main altered pathways in 77 patients with available WES data experiencing an objective response versus others.
Frequently altered genes are grouped according to curated signaling pathways detailed in Supplementary Table 2. Clinical features, TMB, MSI, aneuploidy score and major mutational signatures are indicated in the legend. The bar chart on the top indicates the composition of alterations per sample, and the bar chart on the right indicates the composition of alterations per gene of interest. To compare mutational pathways between patients experiencing an objective response and patients not experiencing an objective response, a Fisher’s exact test was performed. The resulting P values were adjusted using the Benjamini–Hochberg procedure. Results of the statistical tests are provided in Supplementary Tables 13 and 14.
