Extended Data Fig. 2: Overview of patient samples used to generate a single-cell atlas of FASLG expression by endogenous and CAR-engineered cells.
From: CAR-engineered lymphocyte persistence is governed by a FAS ligand–FAS autoregulatory circuit
Summary of (a) cell therapy naive patients with cancer, (b,c) patients with cancer treated with one of two distinct 1928ζ CARs, and (d) healthy donors analyzed using single-cell techniques to generate a FASLG expression atlas. Pictographs and tables display the sample size for each cancer cohort, gender distribution, age range, total number of single-cells analyzed, and reference to the primary datasets. B-ALL = B cell acute lymphoblastic leukemia; CLL = chronic lymphocytic leukemia; COAD = colon adenocarcinoma; DLBC = diffuse large B cell lymphoma; KIRC = kidney renal clear cell carcinoma; LUAD = lung adenocarcinoma; LUSC = lung squamous cell carcinoma; READ = rectal adenocarcinoma; SKCM = skin cutaneous melanoma; UM = uveal melanoma. n.d. = no data.
