Fig. 1: A Smad4-restorable GEMM of PDAC. | Nature Cancer

Fig. 1: A Smad4-restorable GEMM of PDAC.

From: SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence

Fig. 1

a, Schematic of GEMM alleles. rtTA3, third-generation reverse tetracycline transactivator; TRE, tetracycline response element. b, Overall survival of KC-shRen mice and KC-shSmad4 mice (expressing one of two independent Smad4 shRNAs: 591 or 1599) after Dox administration (n = 7 KC-shRen mice; n = 11 KC-shSmad4 mice). Statistical analysis was conducted using a log-rank test. c, H&E staining of primary tumors and liver and lung metastases from KC-shSmad4 mice. Data are representative of ten, six and three independent mice, respectively. d, sWGS analysis of the Cdkn2a/b locus in KC-shSmad4 tumor-derived cell lines (n = 10 independent mice). e, Western blot analysis of Dox response in vitro. Data are representative of six independent KC-shSmad4 cell lines.

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