Fig. 4: AML cases with SLAMF6 display altered T cell composition.
a,b, Frequencies of naive, TEMRA, effector memory and central memory T cells for 39 participants with AML stratified by SLAMF6 expression, based on surface expression of CD45RA and CCR7 within the CD8+ T cell compartment (a) and the CD4+ T cell compartment (b) (Kruskal–Wallis test with Dunn’s post hoc test). Bars indicate median values. c,d, Frequencies of naive cells within the CD8+ (c) and CD4+ (d) T cell compartments for a participant with high SLAMF6 expression and a participant negative for SLAMF6, based on CD45RA and CCR7. e, UMAP and cell type classifications for the T cells from the same cohort of participants with AML based on gene expression profiling by scRNA-seq (28,932 cells from 41 cases). MAIT, mucosal-associated invariant T cell; gdT, gamma delta T cell. f,g, Frequencies of naive, effector and memory T cells within the CD4+ T cell compartment (f) and the CD8+ T cell compartment (g), based on single-cell gene expression signatures for each participant (n = 41 cases; Kruskal–Wallis test with Dunn’s post hoc test). Bars indicate median values.
