Fig. 6: Evaluation of the biocompatibility of the fabricated ECM-inspired hydrogel. | Communications Materials

Fig. 6: Evaluation of the biocompatibility of the fabricated ECM-inspired hydrogel.

From: Extracellular matrix-inspired hydrogel of hyaluronan and gelatin crosslinked via a Link module with a transglutaminase reactive sequence

Fig. 6

a Schematic illustration of the effect of the ECM-inspired hydrogel on cultured cells. b Confocal laser microscopic observation of cells cultured on the fabricated ECM-inspired hydrogel. Live cells were stained with Calcein acetoxymethyl ester (Calcein-AM; green). Scale bar, 100 μm (N = 2). c Schematic illustration of the subcutaneous administration of ECM-inspired hydrogel into mice. The administration site was evaluated 3 days after the administration. d Hematoxylin−eosin staining of the skin tissue of mice administered with fibrin glue, hydrogel without LinkCFQ, and ECM-inspired hydrogel. Mice that received no material were used as the control. Scale bar: 200 μm (upper image) and 100 μm (lower image; N = 2).

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