Fig. 1: A schematic for mechanical force-switchable aqueous organocatalysis.

a ‘ON/OFF’ switching of an organocatalyst system in the presence/absence of ultrasound stimuli leading to controlled products formation from the reactant. Presence of ultrasound stimulus allowed accessibility of an organocatalyst for the chemical reaction (catalysis ON), whereas the catalyst system would be inaccessible for the substrate in the absence of the stimulus (catalysis OFF). b Ester (pNPA, DNPA, and pNPB) hydrolysis reactions are modulated by the switchable catalyst system in aqueous media at ambient conditions.