Fig. 7: Doxorubicin release in zebrafish embryos with and without pulsed light triggers. | Communications Materials

Fig. 7: Doxorubicin release in zebrafish embryos with and without pulsed light triggers.

From: Photoswitchable phospholipids for the optical control of membrane processes, protein function, and drug delivery

Fig. 7

At 48 h post-fertilization, wild-type zebrafish embryos were intravenously injected with either control lipid nanoparticles (LNPs) or photoactivatable LNPs (with azo-PC (paLNP) or red-azo-PC (red-paLNP)), both containing Dox (2/nL of a 3 mg/mL solution). After 24 h, the embryos were exposed to pulsed UV-A (365 nm) or deep-red light (660 nm). a, b Confocal images of the tail region were acquired to assess Dox release (white signal) with and without light exposure. White arrows point to areas with enhanced Dox release. c Presents quantitative image analysis of Dox release; error bars represent the standard error of the mean (SEM), with significance levels indicated by *p < 0.1 and **p < 0.01. Reprinted (adapted) with permission from Small 2021, 17, 21, 1196. Copyright 2021 John Wiley and Sons under license 5897691312413.

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