Fig. 6: Application of silk-based dental implants or coating strategies.
From: Silk-based biomaterial scaffolds for dental tissue regeneration
a A dual-functional Ti-implant coating composed of iron-oxide nanoparticles with SF (FNP/SF-Ti) for synergistic anti-adhesion and Photothermal effect to mitigate implant-associated infection. The inset micro-CT 3D reconstructions show enhanced bone formation in FNP/SF-Ti groups compared to pure Ti after 4 weeks post-implantation. Reprinted with permission from ref. 121. b A 3D customized scaffold composed of SF composites with gingival tissue-derived stem cells for personalized bone therapy. The left panel shows optical images of the scaffolds. Reprinted with permission from ref. 123. c An SF/mesoporous silica nanoparticles (SF/MSN) nanocomposite coating modified TNTs with Ti-implant for a long-term stable drug release and promoting osteogenesis. The left panel displays 3D-reconstructed micro-CT images of the bone surrounding each group of implants at 4- and 8-weeks post-implantation. Reprinted with permission from ref. 124. d A two-layer silk hydrogel microfluidics device is fabricated using gelatin molding and layer-by-layer stacking methods, as reprinted with permission from ref. 168.
