Table 1 Demographic, health and AD-related information

Variables	Below college (n = 92)	College+ (n = 173)	Total (n = 265)	P value
Demographic
Age, mean, years (s.d.)	68.07 (8.41)	66.45 (9.66)	67.01 (9.26)	0.176
Sex, n female (%)	65 (70.7%)	89 (51.4%)	154 (58.1%)	0.004
Race, n white (%)	82 (89.1%)	157 (90.8%)	239 (90.2%)	0.837
Education, mean, years (s.d.)	12.77 (1.39)	17.43 (1.43)	15.82 (2.63)	<0.001
Cardiovascular health, neurological health and mental health
BMI^a, mean, kg/m² (s.d.)	27.47 (4.55)	26.51 (4.48)	26.85 (4.52)	0.102
Recent or remote hypertension^a, n (%)	36 (39.1%)	73 (42.2%)	109 (41.1%)	0.725
Recent or remote hypercholesterolemia^a, n (%)	44 (47.8%)	65 (37.8%)	109 (41.3%)	0.148
Recent or remote cardiovascular incidents^a, n (%)	12 (13.0%)	17 (9.9%)	29 (11.0%)	0.576
Recent or remote traumatic brain injury^a, n (%)	6 (6.7%)	13 (7.8%)	19 (7.5%)	0.948
GDS^a, mean score (s.d.)	1.36 (1.56)	0.91 (1.28)	1.06 (1.40)	0.012
Baseline clinical status, AD-related genetic risk and pathology
CDR-SB^a, mean score (s.d.)	0.19 (0.53)	0.19 (0.64)	0.19 (0.60)	0.976
CDR^a > 0, n (%)	11 (12.0%)	14 (8.1%)	25 (9.4%)	0.422
APOE ε4⁺, n (%)	32 (35.2%)	62 (36.7%)	94 (36.2%)	0.914
CSF pTau^a, mean, pg/ml (s.d.)	55.95 (34.23)	60.12 (31.94)	58.68 (32.74)	0.352
CSF pTau^+a, >67 pg/ml, n (%)	15 (18.3%)	46 (29.7%)	62 (26.1%)	0.080
PiB amyloid^a, mean cortical SUVR (s.d.)	1.30 (0.58)	1.32 (0.64)	1.31 (0.62)	0.772
PiB amyloid^+a, >1.42 SUVR, n (%)	17 (23.3%)	30 (22.4%)	47 (22.7%)	1.00
Other
In-scanner motion^b, mean FD (s.d.)	0.21 (0.07)	0.21 (0.08)	0.21 (0.07)	0.478

The mean (s.d.) or counts (%) of numerical or categorical variables are shown for each education group and the entire sample. Statistical differences between the two education groups were calculated for continuous and categorical variables using t-tests and χ² tests, respectively. Missing data for ‘below college’ (BMI, n = 1; traumatic brain injury, n = 3; GDS, n = 1; CSF pTau, n = 10; PiB amyloid, n = 19; APOE, n = 1). Missing data for ‘college+’ (BMI, n = 1; hypercholesterolemia, n = 1; cardiovascular incidents, n = 2; traumatic brain injury, n = 7; APOE, n = 4; CSF pTau, n = 18; PiB amyloid, n = 39).
Abbreviations, SUVR, standard uptake value ratio; FD, frame displacement.
^aVariables that were measured at different times than the functional MRI (fMRI) scans. The closest point of data collection of each measure to that of the baseline fMRI scan was used (see text for details).
^bIn-scanner motion from all available scanning sessions, compared across the two education groups.

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