Table 2 Linear mixed-model interaction statistics between time, education group and age at baseline on brain system segregation, accounting for different covariates

Covariates	Interaction between time, education group and age at baseline
	n	F	P	2.5% CI	97.5% CI
Accounting for participant demographics
Head motion^a and sex	265	6.814	0.010	−0.021	−0.003
Head motion^a, sex and race^b	265	6.399	0.012	−0.021	−0.002
Accounting for baseline measures of clinical status, AD-related genetic risk and pathology, cardiovascular health, neurological health, and mental health
Clinical status, head motion^a and sex	265	6.652	0.011	−0.021	−0.003
APOE status, head motion^a and sex	260	6.393	0.012	−0.021	−0.003
AD-related pathology, head motion^a and sex	251	3.949	0.048	−0.020	−0.000
Cardiovascular health, head motion^a and sex	265	6.836	0.010	−0.021	−0.003
GDS, head motion^a and sex	264	7.092	0.008	−0.022	−0.003
TBI, head motion^a and sex	255	6.559	0.011	−0.021	−0.003
Clinical status, APOE status, AD-related pathology, cardiovascular health, GDS, TBI, head motion^a, sex and race^b	240	3.257	0.073	−0.020	0.001
Accounting for longitudinal measures of brain structure
Cortical thickness^a, head motion^a and sex	265	5.915	0.016	−0.021	−0.002

^aVariables are longitudinal measures collected at the same time as fMRI scans (for example, head motion, cortical thickness).
^bRace is categorized as white and non-white; <10% of the present sample is non-white.
CI, confidence interval.

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