Extended Data Fig. 3: Comparison of APOE genotype and Aβ phenotypes in induced cortical neurons from AD iPSCs. | Nature Aging

Extended Data Fig. 3: Comparison of APOE genotype and Aβ phenotypes in induced cortical neurons from AD iPSCs.

From: Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Extended Data Fig. 3

Plots show the distribution of (a) Aβ40, (b) Aβ42, (c) Aβ42/40 ratio and (d) protein concentration among different genotypes. X-axes correspond to APOE ε4 genotypes (patients, N = 44 for APOE3/3, N = 44 for APOE3/4, N = 14 for APOE4/4) and Y-axes represent (a) Aβ40 amounts, (b) Aβ42 amounts, (c) Aβ42/40 ratio, and (d) protein concentration of iPSC-derived cortical neurons. Horizontal lines are the median weights within a genotypic group, and error bars indicate standard deviation (S.D.). p > 0.05: not significant (N.S.) (one-way ANOVA with (two-way ANOVA with Tukey’s multiple comparisons test). Abbreviation: APOE, Apolipoprotein E.

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