Extended Data Fig. 3: NAD+-related metabolites of healthy aging groups.
From: Healthy aging and muscle function are positively associated with NAD+ abundance in humans
(a-l) Abundance levels of NAD + -related metabolites in the four muscle health groups, for (A) ADP-ribose, (B) Kynurenic acid, (C) Kynurenine, (D) Methyl-NAM, (E) NAD + , (F) NADH, (G) NADP + , (H) NADPH, (I) Nicotinamide mononucleotide (NMN), (J) Dihydronicotinamide riboside (NRH), (K) Ribose-5P, and (L) Tryptophan. Sample sizes are: young n = 12, older adults; trained n = 17, Normal=17, impaired=6. Significance was determined using an empirical Bayes moderated t test (two-sided, p values adjusted for multiple comparisons between groups, * p < 0.05, ** p < 0.01, *** p < 0.001, n.s. = not significant). Boxplots: Inner line within the box is the median of the data, the box extends to the upper and lower quartile of the dataset (25% of the data above and below the median), whiskers (dashed lines) represent up to 1.5 times the upper or lower quartiles, circles beyond the whisker represent individual data points outside this range. Source data: Statistical_Source_Data.csv, all exact p values for comparison between groups are listed therein.
