Extended Data Fig. 5: Correlation of molecular–physiological phenotypes with metabolites involved in NAD+ synthesis.
From: Healthy aging and muscle function are positively associated with NAD+ abundance in humans
(a) Correlation matrix comparing the paired metabolome (dark blue) and muscle health parameters (light blue) in the older adults (Pearson’s product-moment correlation coefficient, sample size is all older adults, n = 40). The scale ranges from blue (negative correlation), to yellow (no correlation), to red (positive correlation). Inset and cartoon: correlation between metabolites and muscle health parameters are used to reconstruct the network. (b) Abbreviations and measurements of the molecular-physiological phenotypes assessed in this analysis. Note: MOGS3, state 3 respiration upon malate + octanoyl-carnitine + glutamate + succinate, MGS3, state 3 respiration upon malate + glutamate + succinate. Source data: Statistical_Source_Data.csv and physiological data is available in our previous study25.
