Extended Data Fig. 4: Age-associated DNA methylation at macrophage-specific TFs in purified monocyte samples.
From: Inference of age-associated transcription factor regulatory activity changes in single cells
For 4 macrophage-specific TFs that exhibit dysregulation of regulatory activity with age in monocytes/macrophages, as inferred from the TMS 10X scRNA-seq dataset, we display the signed statistical significance (y-axis) of age-association of Illumina 450k DNA methylation probesm as derived from the 1200 purified monocyte sample set from Reynolds et al. In the y-axis we display the sign of the age-associated t-statistic times the negative log10[Q-value], where Q-value is the FDR-estimate. X-axis labels the genomic position of the probes. Probes in red are significantly associated with age (Q < 0.05).
