Extended Data Fig. 1: Protein replicates measured through different PEA panels showed comparable differences. | Nature Aging

Extended Data Fig. 1: Protein replicates measured through different PEA panels showed comparable differences.

From: CSF proteome profiling across the Alzheimer’s disease spectrum reflects the multifactorial nature of the disease and identifies specific biomarker panels

Extended Data Fig. 1

a, Beta coefficients (log2 fold change) of the protein replicates from the comparisons between MCI(Aβ+) or AD and controls (yellow and red respectively) and AD and non-AD dementias (blue). Stars represent the corresponding significant q-value (* q < 0.05, ** q < 0.01, ***q < 0.001) in the discrimination between groups. b, Scatter plots show the correlation of the NPX values (protein abundance) between the protein replicates that showed significant differences across the groups of interest in the complete cohort (n = 797). Regression line and 95% confident intervals are depicted. Insert indicate the spearman correlation coefficient. CON, cognitively unimpaired controls; MCI(Aβ+), mild cognitive impairment with Aβ pathological changes; AD, Alzheimer’s disease; non-AD dem: non-AD dementias.

Back to article page