Extended Data Fig. 6: Additional sensitivity analysis for the CSF biomarker panels discriminating AD from controls or AD from non-AD dementias. | Nature Aging

Extended Data Fig. 6: Additional sensitivity analysis for the CSF biomarker panels discriminating AD from controls or AD from non-AD dementias.

From: CSF proteome profiling across the Alzheimer’s disease spectrum reflects the multifactorial nature of the disease and identifies specific biomarker panels

Extended Data Fig. 6

a, Receiver operating characteristic (ROC) curves showed that the performance of the CSF AD-diagnostic to discriminate AD from controls was similar between APOE4 + (AD = 133; CON = 44) and APOE4- (AD = 88; CON = 125) patients. b, ROC curve depicting the performance of the CSF AD-differential diagnostic discriminating AD from non-AD dementias in the subset of patients in which non-AD dementias was confirmed (AD = 230; cNon-AD dem = 101). Black line is the mean area under the curve (AUC) over all resamplings (1000 repeats of 5-fold cross-validation, gray lines). Inserts outline corresponding AUC and 95% CI. AD, Alzheimer’s disease; CON, cognitively unimpaired controls; cNon-Ad dem: confirmed non-AD dementias.

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