Fig. 1: Higher sTREM2 levels are associated with lower amyloid and tau accumulation as well as cognitive decline in individuals with underlying AD pathology. | Nature Aging

Fig. 1: Higher sTREM2 levels are associated with lower amyloid and tau accumulation as well as cognitive decline in individuals with underlying AD pathology.

From: Microglial activation protects against accumulation of tau aggregates in nondemented individuals with underlying Alzheimer’s disease pathology

Fig. 1

a–d, Results of the linear mixed effect models showing that nondemented A+ individuals with higher baseline sTREM2 levels show less longitudinal accumulation of global amyloid (n = 115) (a), whereas A+T+ individuals show less tau aggregates in III–IV (b) and V–VI (c) Braak regions (n = 38) as well as a decline in the MMSE test scores (n = 53) (d). Amyloid (A+) and tau (T+) pathology were assessed using PET. All variables were z-transformed (Z), and the results were adjusted for multiple comparisons using FDR corrections (two tailed, q < 0.05). Data are presented as mean ± s.e.m.

Back to article page