Extended Data Fig. 5: Age-dependent length correlation persists in transcriptomic and proteomic data of Takemon et al.18, related to Fig. 1.
From: Aging is associated with a systemic length-associated transcriptome imbalance
(a) Relative fold-change of age-dependent transcript change as reported by Takemon et al.18 who integrate information of transcriptomic change in kidneys of 12- and 18-month-old mice versus 6-month-old mice. Length correlations (ρTI) describes Spearman correlation between median transcript length, and relative fold-change of transcripts. We highlight with black circles those 10 genes with a relative fold-decrease and 186 genes with a relative fold-increase identified by an adjusted P value below 0.01 provided by the authors, who obtained P values from DESeq2 using a likelihood ratio test. (b) Relative fold-change of age-dependent protein change as reported by Takemon et al.18 who integrate information of proteomic change in kidneys of 12- and 18-month-old mice versus 6-month-old mice. Proteome length correlations (ρPI) describes Spearman correlation between median transcript length, and relative fold-change of proteins. The thin and thicker black lines indicate outermost boundaries of 80% and 90% of kernel density estimate, respectively. We highlight with black circles those 292 genes with a relative fold-decrease and 186 genes with a relative fold-increase identified by an adjusted P value below 0.01 provided by the authors, who obtained P values from DESeq2 using a likelihood ratio test.
