Extended Data Fig. 7: Robustness of observation of length-associated transcriptome imbalance in humans, related to Fig. 3.
From: Aging is associated with a systemic length-associated transcriptome imbalance
(a) Length correlation after excluding genes annotated for inflammatory and neuronal processes across all 43 tissues of female donors and all 43 tissues of male donors (dark grey) and across 12 brain tissues of female donors and 12 brain tissues of male donors (brown) considered. P values represent two-sided Mann Whitney U tests with U values of 571 and 459 tissues from middle-aged and old donors, respectively. (b) We find a length-associated transcriptome imbalance for tissues from female (top) and male donors (bottom). n=median across all 43 tissues of female donors and all 43 tissues of male donors (dark grey) and across 12 brain tissues of female donors and 12 brain tissues of male donors (brown), respectively. In boxplots center is median, notches bootstrapped 95% confidence interval of median, bounds of box 25% and 75% percentiles, whiskers extend height of box 1.5 times, minima and maxima observed minima and maxima. P values represent two-sided Mann Whitney U tests with U values of 136 and 122 for tissues from middle-aged and old female donors and U values of 148 and 121 from middle-aged and old male donors, respectively. (c) As Fig. 2a but additionally including human tissues.
