Extended Data Fig. 4: Length-associated transcriptome imbalance for individual tissue-age pairs, related to Fig. 1.
From: Aging is associated with a systemic length-associated transcriptome imbalance
(a) Length correlations (ρTI) are defined as Spearman correlation between median transcript length and relative fold-changes observed during aging. Note how most length correlations are negative. (b) Significance of correlation of panel a. Displayed significance values are cropped at 10−50. Note how most P values are lower than 10−20. Significance is determined using t-distribution for two-sided significance test for Spearman correlation66. (c) Number of detected genes underlying the computed length correlations (ρTI). Note how in nearly all cases, the correlation was obtained using more than 5,000 protein-coding genes.
