Fig. 2: Spike-specific antibody responses show pronounced waning after third dose. | Nature Aging

Fig. 2: Spike-specific antibody responses show pronounced waning after third dose.

From: Strong peak immunogenicity but rapid antibody waning following third vaccine dose in older residents of care homes

Fig. 2

a, Spike-specific antibody titer in relation to the day after the third vaccine in donors with prior infection. Orange indicates staff (Spearman’s correlation r = −0.48, P < 0.0001, n = 97) and red indicates residents (two-tailed Spearman’s correlation r = 0.003, P = 0.97, n = 101). All fitted lines are linear regressions. b, Spike-specific antibody titers in relation to the day after the third vaccine in donors without prior infection. Gray indicates staff (Spearman’s correlation r = −0.63, P < 0.0001, n = 86) and black indicates residents (two-tailed Spearman’s correlation r = −0.50, P < 0.0001, n = 57). All fitted lines are linear regressions. c, Spike-specific antibody titer in individual paired samples at two time points following third vaccine dose in donors with prior infection. Two-tailed paired t-test P < 0.0001, n = 32. d, Spike-specific antibody titers in individual paired samples at two time points following third vaccine dose in donors without prior infection. Two-tailed paired t-test P < 0.0044, n = 15.

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