Extended Data Fig. 5: GDF11 treatment reduces weight of CORT mice. | Nature Aging

Extended Data Fig. 5: GDF11 treatment reduces weight of CORT mice.

From: Systemic GDF11 attenuates depression-like phenotype in aged mice via stimulation of neuronal autophagy

Extended Data Fig. 5

(a) Measurement of weight over the weeks of CORT/veh treatment and GDF11/saline injections (nCtrl = 8 mice, nCORT = 16 mice, nGDF11 = 8 mice, nCORT-GDF11 = 16 mice). (b) Same measurement as (a), but only the CORT conditions are represented. (c) Measurement of the weight for CORT and CORT-GDF11 mice (n = 16 mice per group). (d) Measurement of the distance traveled during the Open Field test (nCtrl = 8 mice, nCORT = 15 mice, nGDF11 = 8 mice, nCORT-GDF11 = 16 mice; F (3, 43) = 2). One-way one-sided ANOVA and Tukey’s post hoc test for multiple comparisons; F (DFn, DFd) value shown for each statistical analysis; two-sided Mann–Whitney test for two-group comparisons; P values < 0.05 are represented on the graph; mean ± s.e.m.

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