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Immune aging

‘Lnc-ing’ Treg cells to the aging liver

Nature Aging volume 3, pages 760–761 (2023)Cite this article

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Li and colleagues address the effect of regulatory T (Treg) cells on the aging process and the role of long non-coding RNAs in Treg cell function. They show that a Treg cell-specific and age-induced long non-coding RNA, Altre, protects the aging liver from age-related apoptosis and metabolic abnormalities.

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Fig. 1: Altre maintains immune-metabolic homeostasis in the aging liver by interacting with YY1 to regulate mitochondrial-related gene expression.

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Authors and Affiliations

  1. Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA

    Yonghe Ma & Haiming Cao

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  1. Yonghe Ma
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  2. Haiming Cao
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Correspondence to Haiming Cao.

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The authors declare no competing interests.

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Ma, Y., Cao, H. ‘Lnc-ing’ Treg cells to the aging liver. Nat Aging 3, 760–761 (2023). https://doi.org/10.1038/s43587-023-00439-5

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