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Immune aging

‘Lnc-ing’ Treg cells to the aging liver

Nature Aging volume 3, pages 760–761 (2023)Cite this article

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Li and colleagues address the effect of regulatory T (Treg) cells on the aging process and the role of long non-coding RNAs in Treg cell function. They show that a Treg cell-specific and age-induced long non-coding RNA, Altre, protects the aging liver from age-related apoptosis and metabolic abnormalities.

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Fig. 1: Altre maintains immune-metabolic homeostasis in the aging liver by interacting with YY1 to regulate mitochondrial-related gene expression.

References

  1. Nikolich-Žugich, J. Nat. Immunol. 19, 10–19 (2018).

    Article  PubMed  Google Scholar 

  2. Franceschi, C. et al. Ann. NY Acad. Sci. 908, 244–254 (2000).

    Article  CAS  PubMed  Google Scholar 

  3. Ding, C. et al. Nat. Aging https://doi.org/10.1038/s43587-023-00428-8 (2023).

    Article  PubMed  Google Scholar 

  4. Sakaguchi, S. Annu. Rev. Immunol. 22, 531–562 (2004).

    Article  CAS  PubMed  Google Scholar 

  5. Seifuddin, F. et al. Sci. Data 7, 326 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Iyer, M. K. et al. Nat. Genet. 47, 199–208 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Statello, L., Guo, C. J., Chen, L. L. & Huarte, M. Nat. Rev. Mol. Cell Biol. 22, 96–118 (2021).

    Article  CAS  PubMed  Google Scholar 

  8. Ruan, X. et al. Nat. Commun. 11, 45 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Ruan, X. et al. J. Clin. Invest. 131, e136336 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Shi, Y., Lee, J. S. & Galvin, K. M. Biochim. Biophys. Acta 1332, F49–F66 (1997).

    CAS  PubMed  Google Scholar 

  11. Necsulea, A. et al. Nature 505, 635–640 (2014).

    Article  CAS  PubMed  Google Scholar 

  12. Vollmers, A. C. et al. Proc. Natl Acad. Sci. USA 118, e2016648118 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

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Authors and Affiliations

  1. Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA

    Yonghe Ma & Haiming Cao

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  1. Yonghe Ma
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  2. Haiming Cao
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Correspondence to Haiming Cao.

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The authors declare no competing interests.

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Ma, Y., Cao, H. ‘Lnc-ing’ Treg cells to the aging liver. Nat Aging 3, 760–761 (2023). https://doi.org/10.1038/s43587-023-00439-5

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