Fig. 1: Study overview. | Nature Aging

Fig. 1: Study overview.

From: Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging

Fig. 1

An overview of this study’s data sources, analytical flow and methodology. Created with BioRender.com. The univariate input GWASs of frailty and EAA were reverse coded to align their effects to have positive relationships with healthspan, lifespan and extreme longevity. GWAS, genome-wide association study; EAA, epigenetic age acceleration; CELLECT, CELL-type Expression-specific integration for Complex Traits; IVW, inverse variance weighted; MR LASSO, MR Least Absolute Shrinkage and Selection Operator; HbA1c, glycated hemoglobin; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol.

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