Extended Data Fig. 7: Analysis overview of cis-instrument Mendelian randomization screen of protein coding genes associated with either HbA1c, LDL-C, HDLC, triglycerides, or SBP. | Nature Aging

Extended Data Fig. 7: Analysis overview of cis-instrument Mendelian randomization screen of protein coding genes associated with either HbA1c, LDL-C, HDLC, triglycerides, or SBP.

From: Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging

Extended Data Fig. 7

Results show number of protein-coding genes including in the stages of the colocalization and cis-instrument MR screens. Exposure genome-wide association study data for each of the biomarkers came from HbA1c (N = 344,182); several lipid subfractions including LDL-C (N = 440,546), triglycerides (N = 441,016), and HDL-C (N = 403,943); and SBP (N = 436,419). Outcome data was mvAge (N = 1,958,774). HbA1c, glycated hemoglobin; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; TG, triglycerides; SBP, systolic blood pressure; MR, Mendelian randomization.

Back to article page