Extended Data Fig. 1: Gene-level Manhattan plot of transcriptome-wide association study. | Nature Aging

Extended Data Fig. 1: Gene-level Manhattan plot of transcriptome-wide association study.

From: Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging

Extended Data Fig. 1

TWAS Z-scores (effect estimates of the imputed gene expression on mvAge) are plotted (mvAge N = 1,958,774). The expression quantitative trait loci (eQTL) data are derived from the GTEx Version 8 sparse canonical correlation analysis performed by Feng et al. 2021 (see References). The blue lines represent Z = ± 4.69, corresponding to the Bonferroni adjusted P-value threshold = 1.38 × 10−6 (0.05/36,149 sCCA features available for analysis). Red points and labels indicate genes (Ensembl gene IDs) surpassing the threshold. TWAS, transcriptome-wide association study; sCCA, sparse canonical correlation analysis.

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