Fig. 3: Brains of patients with COVID-19 exhibit increased accumulation of p16 senescent cells.
From: Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology
a, Immunofluorescence images showing DAPI (blue) and p16 (red) immunoreactivity in sections of frontal cortex regions from patients with severe COVID-19 and age-matched non-COVID-related controls. Scale bar, 50 μm. b, Box-and-whisker plots (minimum, 25th percentile; median, 75th percentile; maximum) showing percentage of p16-positive cells. Each data point represents a single patient analyzed, with a total of 2,794,379 individual brain cells across seven patients with COVID-19 and eight non-COVID-19. Two-tailed Student’s t-test.
