Extended Data Fig. 6: Changes in average profiles of histone marks and ATAC-seq signals at promoters and enhancers in aging NSPCs. | Nature Aging

Extended Data Fig. 6: Changes in average profiles of histone marks and ATAC-seq signals at promoters and enhancers in aging NSPCs.

From: Transcriptional and epigenetic dysregulation impairs generation of proliferative neural stem and progenitor cells during brain aging

Extended Data Fig. 6

a, Average profile of H3K4me3 and H3K27me3 at the promoters of all genes spanning TSSs in young and aged NSPCs (Two-sided Wilcoxon rank sum test, H3K4me3 data p-value = 0.2209, H3K27me3 data p-value = 6.69E-15). b, Average profile of H3K27ac signals spanning the center of enhancers of all genes in young and aged NSPCs (Two-sided Wilcoxon rank sum test, H3K27ac data p-value = 0.2684). c, Pearson correlation analysis of fold changes of RNA levels and promoter H3K4me3 signals of age-dependent genes. 95% confidence interval. d, Pearson correlation analysis of fold changes of RNA levels and enhancer H3K27ac signals of age-dependent genes. 95% confidence interval. e, f, Average profiles of ATAC- seq at promoters and enhancers of all genes show no genome-wide changes of chromatin accessibility across the regulatory elements during NSPC aging (Two-sided Wilcoxon rank sum test, promoter profile p-value = 0.9261, enhancer profile p-value = 0.6969).

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