Extended Data Fig. 4: Aging-associated mechanisms are altered during MASLD development. | Nature Aging

Extended Data Fig. 4: Aging-associated mechanisms are altered during MASLD development.

From: Aging promotes metabolic dysfunction-associated steatotic liver disease by inducing ferroptotic stress

Extended Data Fig. 4

GSEA of bulk liver RNA seq data from Duke MASLD patients (GSE213623) revealed that (A) genes related to longevity and its associated mechanisms (for example NAD metabolism, sirtuins) are depleted, (B) while genes related to senescence are highly enriched in the transcriptomics of MASLD patients. (C) AHGS was applied to deconvolute bulk liver RNA seq data (GSE135251, heathy control n = 13; MASH n = 12). AHGS is enriched in transcriptomes of MASH patients and distinguishes MASH patients from healthy controls. Boxplot shows the upper quantile (75%), median (50%) and lower quantile (25%) of overall data distribution. p-values were calculated using: permutation test, then adjusted for multiple comparison testing using the Benjamini-Hochberg method in A, B; Wilcoxon Rank Sum test in C.

Back to article page