Extended Data Fig. 7: BMMs-EVs containing miRNAs enrichment pathways. | Nature Aging

Extended Data Fig. 7: BMMs-EVs containing miRNAs enrichment pathways.

From: Aged bone marrow macrophages drive systemic aging and age-related dysfunction via extracellular vesicle-mediated induction of paracrine senescence

Extended Data Fig. 7

a, Expression level of miRNA-378a in BMMs isolated from young (3 m, male mice) and aged mice (24 m, male mice) (n = 6 young mice; n = 5 aged mice). b, Expression level of miRNA-378a in liver, adipose tissues and muscle of young mice after YBMM-EVs or ABMM-EVs treatment (n = 4 mice for YBMM-EVs; n = 3 mice for ABMM-EVs). c, Expression level of miRNA-191 in BMMs and their derived EVs (n = 3 mice). d, Bar plots of enriched terms of miR-378a and miR-191. Data are shown as mean ± SEM. *P < 0.05; **P < 0.01were determined using two-tailed t-test in a, b (liver and muscle) and c (BMM-EVs) and two-tailed t-test with a Welch’s correction in b (adipose tissues) and c (BMMs).

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