Extended Data Fig. 6: Transcriptome-wide predictability changes with age: excluding the age group of 70–79.
From: Loss of coordination between basic cellular processes in human aging
a) Distribution of p-values for the regression of predictability values within each age group against the mean age of the age group. Red line: p-value distribution obtained from the real data. Grey background: average p-value distribution across 100 permutations of the age groups. Black lines: 5 individual permutations randomly picked from the background. The dashed vertical line indicates the highest p-value among the genes considered statistically significant in each tissue (orange and blue bars in C). P-values correspond to the two-sided t-test on regression coefficients, without multiple testing correction. b) Heatmap of the predictability slopes across all genes, independently of significance level, for which the regression analysis was performed in all 8 tissues. These genes had a high average predictability in all 8 tissues. c) Number of genes with predictability increase (blue) and decrease (orange) among the top 100 most significant genes per tissue.
