Extended Data Fig. 10: Contribution of within-set and between-set correlation changes to age-related predictability changes.
From: Loss of coordination between basic cellular processes in human aging
a) Contribution of within-set and between-set correlation changes to age-related predictability changes. Predictability changes are represented as the weighted averages (opposed to weighted sums in Figure 4a) of age-related correlation changes between genes with increasing (top) or decreasing (bottom) predictability with age and their regulatory neighbours within (full color) or between (transparent) the same gene set. Correlation changes with age are quantified as the slope of the correlation ~ Age regression. These values are weighted with the coefficients of the regulatory model, so that correlation changes in strongly connected regulatory neighbours (higher coefficient) are prioritized. b) Regulatory neighbourhood of ATP6V0D1. This gene encodes for a subunit of the transmembrane (V0) domain of vacuolar ATPase. Nodes represent genes, colored by predictability slope in Artery - Tibial. Connections between nodes represent gene-gene relationships captured by the regulatory model.
