Fig. 3: Factors underlying age-related predictability changes.
From: Loss of coordination between basic cellular processes in human aging
a, Possible factors explaining observations of low predictability and resulting comparisons of observed values (in the original data, x axis) versus predicted values (data reconstructed with our regulatory model, y axis). Top left, low average expression of the target gene results in noisy quantifications. Top right, low variance of the target gene results in almost constant expression values. Correlation approaches thus capture noisy fluctuations around the mean. Bottom left, loss of correlation with the regulatory neighborhood results in a failure of the model to correctly capture the expression pattern of the target gene. b, Expression slope across age (x axis) against variance slope across age (y axis) for background genes (small light gray points). Top 100 significant genes with predictability increase (large blue points) or decrease (large orange points) with age. Age-related variance changes are cropped to remove outliers (see Extended Data Fig. 9a for full data). c, Number of genes with predictability decrease (orange) or increase (blue) in each of the three scenarios tested: ‘Expression change’, ‘Variance change’ or ‘Total’ (total number of predictability hits, for reference).
