Extended Data Fig. 6: Performance comparison to previous epigenetic clocks.
From: Somatic mutation as an explanation for epigenetic aging
a) Pearson r between predicted and chronological age for Hannum, Horvath, and PhenoAge clocks across the same samples as Fig. 4b (n = 1,601). Predictions were done using the subset of features from each clock that existed in our methylation data after quality control (66%, 63%, and 61% of CpG sites from the Hannum, Horvath, and PhenoAge clocks, respectively). The performance of this study’s methylation clock is not shown as it is inherently fit to the TCGA dataset in 5-fold CV. b) Pearson r between predicted and chronological age for Hannum, Horvath, and PhenoAge clocks after re-fitting (Methods). Same samples as (a). The performance of the methylation clock trained in this study (‘This study’) is shown for reference.
