Extended Data Fig. 7: 753b is not cytotoxic to HCC cells in vitro. | Nature Aging

Extended Data Fig. 7: 753b is not cytotoxic to HCC cells in vitro.

From: A BCL-xL/BCL-2 PROTAC effectively clears senescent cells in the liver and reduces MASH-driven hepatocellular carcinoma in mice

Extended Data Fig. 7

A. Cell viability of human HCC cells, HepG2 and Huh7, 72 h after treatment with increasing concentrations of ABT263 and 753b in cell culture. EC50, half-maximal effective concentration. The data presented are mean ± SD (n = 6 technical replicates) of a reprentative assay. Similar results were observed in two additional assays. B. Representative western blotting images of BCL-xL, BCL-2, BCL-w and MCL-1 in HepG2 cells after they were treated with increasing concentrations of ABT263 and 753b for 16 h. β-actin was used as a loading control.

Source data

Back to article page