Extended Data Fig. 4: Differential gene expression of oligodendrocyte developmental states show unchanged OPC to oligodendrocyte maturation in amyloid-carrying APPPS1 mice. | Nature Aging

Extended Data Fig. 4: Differential gene expression of oligodendrocyte developmental states show unchanged OPC to oligodendrocyte maturation in amyloid-carrying APPPS1 mice.

From: Interleukin-12 signaling drives Alzheimer’s disease pathology through disrupting neuronal and oligodendrocyte homeostasis

Extended Data Fig. 4

a,b,c. Volcano plots showing differentially regulated genes across all genotypes in MOL (a), MFOL (b) and OPC (c). Pseudotime analysis for genes involved in positive regulation (GO:0048714) of oligodendrocyte maturation (d-e) and negative regulation (GO:0048715) of oligodendrocyte maturation (f-g) show no strong difference across genotypes.

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