Fig. 6: IL-12 signaling leads to transcriptional changes in mouse hippocampal and cortical neurons. | Nature Aging

Fig. 6: IL-12 signaling leads to transcriptional changes in mouse hippocampal and cortical neurons.

From: Interleukin-12 signaling drives Alzheimer’s disease pathology through disrupting neuronal and oligodendrocyte homeostasis

Fig. 6

a, Representative images of PV+ interneurons in the cortex and hippocampus of APPPS1.Il12b−/− mice. b, Quantification of PV+ interneurons comparing WT (cortex mean = 23.49 ± s.e.m.; CA1 mean = 5.868 ± s.e.m.), APPPS1 (cortex mean = 17.67 ± s.e.m.; CA1 mean = 4.653 ± s.e.m.) and APPPS1.Il12b−/− mice (cortex mean = 24.66 ± s.e.m.; CA1 mean = 6.324 ± s.e.m.) (n = 8 per genotype), one-way ANOVA, df = 2, F = 4.620, P = 0.232 for CA1 and one-way ANOVA, df = 2, F = 15.68, P < 0.0001 for cortex. c, GO analysis of genes upregulated in subiculum comparing APPPS1 versus WT mice, APPPS1.Il12b−/− versus WT mice, APPPS1 versus APPPS1.Il12b−/− mice and APPPS1.Il12b−/− versus APPPS1 mice. d,e, Using CellPhoneDB, dot plot showing the predicted receptor–ligand interactions between neuronal cell types (d) and oligodendrocytes (e) in WT, APPPS1 and APPPS1.Il12b−/− mice. P values are indicated by the circle size, and means of the average expression level are color coded. df, degrees of freedom; exp, expression.

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