Extended Data Fig. 6: Targeted modifications at age-hypomethylated regions. | Nature Aging

Extended Data Fig. 6: Targeted modifications at age-hypomethylated regions.

From: Epigenetic editing at individual age-associated CpGs affects the genome-wide epigenetic aging landscape

Extended Data Fig. 6

a) Genomic tracks of differential DNAm at day 3 in a 10k base window centered at the corresponding target site (dashed vertical line) at five CpGs that lose DNAm with age. b) Kernel density estimate revealing no methylation changes at 692 predicted off-target binding sites (sequence homology) compared to all CpGs on BeadChip. c) Multivariate kernel density estimate and linear regression (Pearson correlation) comparing DNAm changes with epigenome editing between PDE4C and hypo-CpGs.

Back to article page