Extended Data Fig. 2: MTtRFs decline, NtRFs and RGTTCRA-tRFs elevate in both Male and Female PD patients vs. controls. | Nature Aging

Extended Data Fig. 2: MTtRFs decline, NtRFs and RGTTCRA-tRFs elevate in both Male and Female PD patients vs. controls.

From: Pre-symptomatic Parkinson’s disease blood test quantifying repetitive sequence motifs in transfer RNA fragments

Extended Data Fig. 2

a. Density plots of post-mortem interval in female and male samples (left, right) and patients’ age (upper and lower panel). Note that PD, but not AD appears to shorten patients’ life span. b, c. Volcano plots for male (A) and Female (B) CSF samples. Each dot is a tRF. X: log2(Fold Change) of PD/Ctrl levels. Y: -log10(FDR adjusted p value). Horizontal and vertical lines: FDR < 0.05; log2(FC) > 1 or <-1. Left: NtRFs, right: MTtRFs. Dot colors: tRFs’ length. d. Scheme of tRNA breakdown into tRF types by Angiogenin (Ang) or Dicer (DICR). e. Segregation of PD-modified tRFs (Fig. 1b) to subtypes as in A. Each dot is a tRF. X: log2(Fold Change) of PD/Ctrl levels. Y: -log10(FDR adjusted p value). Background colors: NtRFs (blue), MTtRFs (green). f, g. Volcano plots for male (E) and Female (F) CSF samples. PD CSF NtRFs segregated into RGTTCRA-carrying and lacking tRFs. Blue thick line: FDR = 0.05. Grey line: unadjusted p = 0.05. Each dot is a tRF. X: log2(Fold Change) of PD/Ctrl levels. Y: -log10(FDR adjusted p value). Dot colors: tRFs’ length. h. As in A for 8 PD SN samples.

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